Ukrainian Cities Hit by Russian Drone Attacks, Resulting in Casualties
Russian drone attacks struck multiple Ukrainian cities overnight on September 21-22, 2025, resulting in casualties and significant damage across at least seven locations.

Russian forces launched a large-scale drone assault on Ukraine during the night of September 21 to 22, 2025, targeting several cities and resulting in civilian casualties and infrastructure damage. According to Ukrainian authorities, the attack involved 141 drones, including Shahed and Gerbera models, and struck at least seven different locations across the country.
Scale and Impact of the Attacks
The Ukrainian Air Force reported that the drone barrage was one of the largest in recent months, with approximately 80 Shahed drones among those deployed. The strikes caused explosions and fires in residential areas, damaging homes, public buildings, and energy infrastructure. Emergency services responded to multiple incidents, working through the night to extinguish fires and assist the injured. Local officials confirmed that there were both fatalities and injuries, though the exact number of casualties was still being assessed as of Monday morning.
Ukrainian Response and Ongoing Threats
Ukrainian air defenses managed to intercept a significant number of incoming drones, but several managed to evade defenses and hit their targets. Authorities warned that the continued use of drones by Russian forces poses a persistent threat to civilian populations and critical infrastructure. Ukrainian officials reiterated calls for increased international support, particularly in the form of advanced air defense systems, to help counter the ongoing aerial campaign.
Broader Context and International Reactions
The latest wave of drone attacks comes amid heightened tensions and ongoing hostilities along the front lines. International observers noted that the strikes appeared to be part of a broader escalation, with both sides reporting deadly overnight attacks. The international community has condemned the targeting of civilian areas and called for renewed efforts to de-escalate the conflict. As recovery efforts continue, Ukrainian authorities are urging residents to remain vigilant and to heed official warnings regarding air raid alerts.